The Neuron SpikerBox is strictly for cockroaches and is precisely built for neuron experiments which are done in the specific frequency range. And the main difference is in the time length of the spikes.

 For example, muscle spikes are longer than neuron spikes. On the other hand, the Claw Bundle can perform the same experiments as the Muscle SpikerBox - The only thing the Claw Bundle lacks is a built-in speaker, compared to the Muscle SpikerBox.